GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7818688 | 1 | rs11780931 | chr8:96043829 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -4.39 | 1.26E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs7818688 | 1 | rs11781040 | chr8:96041746 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -4.46 | 9.09E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs11782652 | 1 | rs11782652 | chr8:82653644 | CHMP4C | chr8:82644688-82671746:+ | -0.76 | -13.98 | 6.9E-41 | Epithelial ovarian cancer;Ovarian cancer |
| BRCA | cis | rs7818688 | 1 | rs11786878 | chr8:96033292 | C8orf38 | chr8:95908040-96088396:+ | -0.18 | -3.98 | 7.29E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs6583954 | 1 | rs117897483 | chr10:96471787 | HELLS | chr10:96305543-96361855:+ | 0.12 | 3.48 | 0.000528 | Migraine |
| BRCA | cis | rs9638182 | 1 | rs1178977 | chr7:72857049 | MLXIPL | chr7:73007524-73038870:- | 0.24 | 4.31 | 1.78E-5 | Triglycerides |
| BRCA | cis | rs11789898 | 1 | rs11789898 | chr9:136925663 | BRD3 | chr9:136895454-136933655:- | 0.22 | 5.45 | 6.13E-8 | Platelet count |
| BRCA | cis | rs1577917 | 1 | rs117907570 | chr6:86601283 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -19.33 | 1.23E-71 | Response to antipsychotic treatment |
| BRCA | cis | rs11792861 | 1 | rs11792861 | chr9:111809295 | C9orf5 | chr9:111777416-111882225:- | 0.17 | 5.14 | 3.32E-7 | Menarche (age at onset) |
| BRCA | cis | rs11603691 | 1 | rs117981067 | chr11:57064112 | PRG2 | chr11:57151267-57191532:- | -0.21 | -3.53 | 0.000434 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs11799420 | 1 | rs11799420 | chr1:171652978 | VAMP4 | chr1:171669298-171711214:- | -0.12 | -3.47 | 0.000546 | Hippocampal atrophy |
| BRCA | cis | rs4077468 | 1 | rs11801695 | chr1:205916175 | PM20D1 | chr1:205797154-205819245:- | -0.2 | -6.07 | 1.79E-9 | Cystic fibrosis-related diabetes |
| BRCA | cis | rs11799420 | 1 | rs11801846 | chr1:171674241 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.42 | 7.51E-8 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs11802265 | chr1:171649936 | VAMP4 | chr1:171669298-171711214:- | 0.16 | 4.71 | 2.79E-6 | Hippocampal atrophy |
| BRCA | cis | rs11799420 | 1 | rs11803174 | chr1:171674338 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.42 | 7.51E-8 | Hippocampal atrophy |